##plugins.themes.academic_pro.article.sidebar##
Submitted
Dec 17, 2023
Published
Mar 1, 2024
Download
Statistic
Read Counter : 1452
Download : 386
Downloads
Download data is not yet available.
Main Article Content
Abstract
The search for alternatives to chemical pharmaceutical products remains an urgent and crucial step for humanity. In this regard, the use of plants presents an ideal approach for such biological studies. Arbutus unedo L., which belongs to the family Ericaceae, is one of the species that holds significant importance in traditional pharmaceutical uses. In Algeria, the use of this species in traditional treatment is generally rare. Therefore, this study aims to highlight its medicinal importance and the proper method for extracting its bioactive elements. To achieve this, the biological activity of leaves including total phenolic content (TPC), DPPH assay, and total flavonoid content (TFC), were assessed under four different drying temperatures (shade-drying, sun-drying, 40°C and 60C°) and two extraction methods after maceration (centrifugation, filtration). The results have indicated that these processes have affected the final accumulation of polyphenols and antioxidant activity in the leaf extracts. Additionally, it has been highlighted that the centrifugation method extracts a higher biochemical amount, especially after drying at 40°C. Furthermore, Arbutus unedo L. leaves should be considered a promising source of natural compounds to be used as ingredients in various fields.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
Zemour, K., Chouhim, K. M. A., Labdelli, A., Mairif, M., Ardjane, T. E. A., Moussaoui, B., Zemour, H., & Laafer, M. (2024). Improvement of the antioxidant potential: impact of drying and extraction techniques on polyphenols in Arbutus unedo L. leaf aqueous extract. Journal of Agriculture and Applied Biology, 5(1), 35-47. https://doi.org/10.11594/jaab.05.01.03
References
Abebe, A., Hilawea, K. T., Mekonnen, A., Tigineh, G. T., Sitotaw, B., Liyew, M., & Wubieneh T.A. (2022). Assessment on antioxidant activity of the aqueous leaf extracts of Combretum mi-crophyllum and the effect of Co (II)-leaf extract complex on antibacterial activity of leaf ex-tracts of the plant material. Scientific African, 18, e01432. CrossRef
Abidi, E., Habib, J., Yassine, A., Chahine, N., Mahjoub, T., & Elkak A. (2016). Effects of methanol extracts from roots, leaves, and fruits of the Lebanese strawberry tree (Arbutus andrachne) on cardiac function together with their antioxidant activity. Pharmaceutical Biology, 54(6), 1035-1041. CrossRef
Ahdaa, M., Jaswirb, I., Khatibd, A., Ahmed, Q. E., Mahfudha, N., & Ardini, Y.D. (2023). A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mecha-nisms of action, and clinical study. International journal of food properties, 26(1), 1414–1425. CrossRef
Ait lhaj, Z., Taghzouti, K., Bouyahya, A., Diria, G., Bakhy, K., & Bchitou R. (2022).Phenolic com-position and antioxidant activity of leaves of strawberry tree (Arbutus unedo L.) popula-tions from Morocco. Phytothérapie, 20(4-5), 192–204. CrossRef
Alghoraibi, I., Soukkarieh, C., Zein, R., Alahmad, A., Walter, J.G., & Daghestani, M. (2020). Aqueous extract of Eucalyptus camaldulensis leaves as reducing and capping agent in biosynthesis of silver nanoparticles. Inorganic and Nano-Metal Chemistry, 50(10), 1–8. CrossRef
Anwar F., Kalsoom U., Sultana B., Mushtaq M., Mehmood T., & Arshad H. A. (2013). Effect of dry-ing method and extraction solvent on the total phenolics and antioxidant activity of cauli-flower (Brassica oleracea L.) extracts. International Food Research Journal, 20(2), 653-659. Direct Link.
Ateş, U., Karakaya, O., Çelik, S.M., & Faizy, A.H. (2022). Bioactive compounds of strawberry tree (Arbutus unedo L.) genotypes grown in the East Black Sea and Marmara region. Turkish Journal of Food and Agriculture Sciences, 4 (2), 29-33. CrossRef
Baibuch, S., Zema, P., Bonifazi, E., Cabrera, G., Mondragón Portocarrero, A. D. C., Campos, C., & Malec, L. (2023). Effect of the drying method and optimization of extraction on antioxidant activity and phenolic of rose petals. Antioxidants, 12(3), 681. CrossRef
Bafandeh, S., Khodadadi, E., Ganbarov, K., Asgharzadeh, M., Köse, S., & Samadi Kafil, H. (2023). Natural products as a potential source of promising therapeutics for COVID-19 and viral diseases. Evidence-Based Complementary and Alternative Medicine, 2023, 5525165 Cross-Ref
Bakchiche, B., Gherib, A., Smail, A., Custódia, G., & Graça, M. M. (2013). Antioxidant activities of eight Algerian plant extracts and two essential oils. Industrial Crops and Products, 46: 85–96. CrossRef
Bebek Markovinovi´c, A., Brˇci´c Karaˇconji, I., Jurica, K., Lasi´c, D., Skendrovi´c Babojeli´c, M., Duralija, B., Šic Žlabur, J., Putnik, P., & Bursa´c Kovaˇcevi´c, D. (2022). Strawberry tree fruits and leaves (Arbutus unedo L.) as raw material for sustainable functional food processing: a review. Horticulturae, 8(10), 881. CrossRef
Benjamin, M. A. Z., Ng, S. Y., Saikim, F. H., & Rusdi, N. A. (2022). The effects of drying techniques on phytochemical contents and biological activities on selected bamboo leaves. Molecules, 27(19), 6458. CrossRef
Bertsouklis, K. F., Daskalakis, I., Biniari, K., & Papafotiou, M. (2021). Comparative study of poly-phenolic content and antioxidant capacity in fruits of Arbutus unedo, A. andrachne and their natural hybrid A.× andrachnoides. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 49(1), 12165. CrossRef
Bié, J., Sepodes, B., Fernandes, P.C.B. & Ribeiro, M.H.L. (2023). Polyphenols in health and disease: gut microbiota, bioaccessibility, and bioavailability. Compounds 3(1), 40-72. CrossRef
Chaikhong, K., Chumpolphant, S., Rangsinth, P., Sillapachaiyaporn, C., Chuchawankul, S., Ten-comnao, T., & Prasansuklab, A. (2023). Antioxidant and anti-skin aging potential of selected Thai plants: In vitro evaluation and in silico target prediction. Plants, 12(1), 65. CrossRef
Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Abdull Razis, A. F., Modu, B., Calina, D., & Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1158198. CrossRef
Cör Andrejc, D., Butinar, B., Knez, Ž., Tomažiˇc, K., & Knez Marevci, M. (2022). The effect of dry-ing methods and extraction techniques on oleuropein content in olive leaves. Plants (Basel), 11(7), 865. CrossRef
Doudach, L., Naceiri Mrabti, H., Al-Mijalli, S. H., Kachmar, M. R., Benrahou, K., Assaggaf, H., Qasem, A., Abdallah, E. M., Rajab, B. S., Harraqui, K., Mekkaoui, M., Bouyahya, A., & El Ab-bes Faouzi, M. (2023). Phytochemical, antidiabetic, antioxidant, antibacterial, acute and sub-chronic toxicity of moroccan Arbutus unedo leaves. Journal Pharmacopuncture, 26(1), 27-37. CrossRef
Dutta, A. K., Gazi, M. S., & Uddin, S. J. (2023). A systemic review on medicinal plants and their bi-oactive constituents against avian influenza and further confirmation through in-silico analysis. Heliyon, 9, e14386. CrossRef
El Cadi, H., El Cadi, A., Kounnoun, A., Oulad El Majdoub, Y., Palma, L. M., Brigui, J., Dugo, P., Mondello, L., & Cacciola, F. (2020). Wild strawberry (Arbutus unedo): Phytochemical screening and antioxidant properties of fruits collected in northern Morocco. Arabian Jour-nal of Chemistry, 13(8), 6299-6311. CrossRef
El-Desouky, T. A. (2021). Evaluation of effectiveness aqueous extract for some leaves of wild edible plants in Egypt as anti-fungal and anti-toxigenic. Heliyon, 7(2), e06209. CrossRef
El Gamal, R., Song, C., Rayan, A. M., Liu, C., Al-Rejaie, S., & ElMasry, G. (2023). Thermal degrada-tion of bioactive compounds during drying process of horticultural and agronomic prod-ucts: A comprehensive overview. Agronomy, 13(6), 1580. CrossRef
El Mekkaoui, A., Khamar, M., Slimani, C., Nounah, A., Cherkaoui, E., Benradi, F., & Chaimae Raisi, C. (2023). Phytochemical studies and in vitro evaluation of the antioxidant activity of some medicinal and aromatic plants from Morocco. Notulea Scitia Biologicae, 15(1), 11423. CrossRef
El Zerey-Belaskri, A., Belyagoubi-Benhammou, N., & Benhassaini, H. (2022). From traditional knowledge to modern formulation: potential and prospects of Pistacia atlantica desf. es-sential and fixed oils uses in cosmetics. Cosmetics, 9(6), 109. CrossRef
Erdogan, G., & Uysal, T. (2020). Characterization of antioxidant properties of strawberry tree (Arbutus unedo L.) and trace elements determination. Journal of Research in Pharmacy, 24(5), 774–785. CrossRef
Erkekoglou, I., Nenadis, N., Samara, E., & Mantzouridou, F. T. (2017). Functional teas from the leaves of Arbutus unedo: phenolic content, antioxidant activity, and detection of efficient radical scavengers. Plant Foods for Human Nutrition, 72(2), 176-183. CrossRef
Frimpong, E. K., Asong, J. A., & Aremu, A. O. (2021). A review on medicinal plants used in the management of headache in Africa. Plants, 10(10), 2038. CrossRef
García-Ramón, F., Malnati-Ramos, M., Rios-Mendoza, J., Vivar-Méndez, J., Nieva-Villegas, L.M., Cornelio-Santiago, H.P., Sotelo-Méndez, A. (2023). Avocado Hass peel from industrial by-product: effect of extraction process variables on yield, phenolic compounds and antioxi-dant capacity. Frontiers in Sustainable Food Systems, 7:1255941. CrossRef
Guclu, G., Keser, D., Kelebek, H., Keskin, M., Emre Sekerli, Y., Soysal, Y., & Selli, S. (2021). Impact of production and drying methods on the volatile and phenolic characteristics of fresh and powdered sweet red peppers. Food Chemistry, 338, 128129. CrossRef
Habachi, E., Rebey, I. B., Dakhlaoui, S., Hammami, M., Sawsen, S., Msaada, K., Merah, O., & Bour-gou, S. (2022). Arbutus unedo: Innovative source of antioxidant, anti-inflammatory and anti-tyrosinase phenolics for novel cosmeceuticals. Cosmetics, 9(6), 143. CrossRef
Haris, A., Nawan, N. A., Mei, C. A. L., Sani, S. A., & Najm, S. U. F. S. (2023). Medicinal plant applica-tions as traditional and complementary medicine by sabah ethnicities and the regulations and economic view in Malaysia's healthcare industry: A mini review. Pharmacognosy Re-views, 17(33), 1-10. CrossRef
Hmaidosh D., Ali M., & Salame R. (2020). Evaluation of antioxidant activity and the phenolic composition of Syrian Arbutus andrachne L. Future of Food: Journal on Food, Agriculture and Society, 8 (3): 1-7. Direct Link.
Jurič A., Gašić U., Karačonji I.B., Jurica K., & Milojković-Opsenica D. (2020). The phenolic profile of strawberry tree (Arbutus unedo L.) honey. Journal of the Serbian Chemical Society, 85 (8): 1011–1019. Direct Link.
Kachkoul, R., Squalli Housseini, T., Mohim, M., El Habbani, R., Miyah, Y., & Lahrichi, A. (2019). Chemical compounds as well as antioxidant and litholytic activities of Arbutus unedo L. leaves against calcium oxalate stones. Journal of integrative medicine, 17(6):430–437. CrossRef
Kim, Y.J. & Kang, K.S. (2023). The phytochemical constituents of medicinal plants for the treatment of chronic inflammation. Biomolecules, 13, 1162. CrossRef
Kumar, A.P.N., Kumar, M., Jose, A., Tomer, V., Oz, E., Proestos, C., Zeng, M., Elobeid, T.K.S., & Oz, F. (2023). Major phytochemicals: recent advances in health benefits and extraction method. Molecules. 28(2):887. CrossRef
Labdelli, A., Zemour, K., Simon, V., Cerny, M., Adda, A., & Merah, O. (2019). Pistacia atlantica Desf., a source of healthy vegetable oil. Applied Sciences, 9(12), 2552. CrossRef
Lang, H. G., Lindemann, J. S., Ferreira, D. C., Hoffmann, J. F., Vanier, N. L., & de Oliveira, M. (2019). Effects of drying temperature and long-term storage conditions on black rice phe-nolic compounds. Food Chemistry, 287, 197–204. CrossRef
Laouicha S., Senator A., Kherbache A., & Bouriche H. (2020). Total phenolic contents and an-tioxidant properties of Algerian Arbutus unedo L. extracts. Journal of Drug Delivery and Therapeutics, 10(3-s): 159-168. CrossRef
Lee, S. Y., Ferdinand, V., & Siow, L. F. (2022). Effect of drying methods on yield, physicochemical properties, and total polyphenol content of chamomile extract powder. Frontiers Pharma-cology, 13, 1003209. CrossRef
Lehfa, F., Belkhodja, H., & Sahnouni, F. (2023) Phytochemical screening, antioxidant and anti-inflammatory activities of polyphenolic extracts of strawberry-tree fruits (Arbutus unedo L). Journal of Applied Biotechnology Reports, 10(2), 992-999. CrossRef
Lenzi, M., Turrini, E., Catanzaro, E., Cocchi, V., Guerrini, A., Hrelia, P., Gasperini, S., Stefanelli, C., Abdi Bellau, M. L., Pellicioni, V., Tacchini, M., Greco, G., & Fimognari, C. (2022). In vitro in-vestigation of the anticancer properties of Ammodaucus Leucotrichus Coss. & Dur. Pharma-ceuticals, 15(12), 1491. CrossRef
Martemucci, G., Costagliola, C., Mariano, M., D’andrea, L., Napolitano, P., & D’Alessandro, A. G. (2022). Free radical properties, source and targets, antioxidant consumption and health. Oxygen, 2(2), 48–78. CrossRef
Miguel, M. G., Faleiro, M. L., Guerreiro, A. C., & Antunes, M. D. (2014). Arbutus unedo L.: chemical and biological properties. Molecules, 19(10), 15799–15823. CrossRef
Morales, D. (2022). Use of strawberry tree (Arbutus unedo) as a source of functional fractions with biological activities. Foods, 11(23), 3838. CrossRef
Morgado, S., Morgado, M., Plácido A. I., Roque, F., & Duarte, A. P. (2018). Arbutus unedo L.: From traditional medicine to potential uses in modern pharmacotherapy. Journal of Ethnophar-macology, 225, 90-102. CrossRef
Moualek, I., Iratni, A.G., Mestar, G.N., Souad, L., & Houali, K. (2016). Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract. Asian Pacific Journal of Tropical Biomedicine, 6(11), 933-944. CrossRef
Mrabti H.N., Marmouzi I., Sayah K., Chemlal L., El Ouadi Y., Elmsellem H., Cherrah Y., & Faouzi M.A. (2017). Arbutus unedo L. aqueous extract is associated with in vitro and in vivo antiox-idant activity. Journal of materials and Environmental Sciences, 8(1): 217–224. Direct Link.
Muflihah, Y. M., Gollavelli, G., & Ling, Y. C. (2021). Correlation study of antioxidant activity with phenolic and flavonoid compounds in 12 Indonesian indigenous herbs. Antioxidants, 10(10), 1530. CrossRef
Nafeh, G., Abi Akl, M., Samarani, J., Bahous, R., Al Kari, G., Younes, M., Sarkis, R., Rizk, S. (2023). Urtica dioica leaf infusion enhances the sensitivity of triple-negative breast cancer cells to cisplatin treatment. Pharmaceuticals, 16, 780. CrossRef
Nisar, B., Sultan, A., & Rubab, S. (2018). Comparison of medicinally important natural products versus synthetic drugs-A short commentary. Natural Products Chemistry & Research, 6, 2. CrossRef
Nurhaslina, C. R., Andi Bacho, S., & Mustapa, A. N. (2022). Review on drying methods for herbal plants. Materials Today: Proceedings, 63(1), S122-S139. CrossRef
Pacheco-Hernández, Y., Villa-Ruano, N., Lozoya-Gloria, E., Barrales-Cortés, C. A., Jiménez-Montejo, F. E., & Cruz-López, M. D. C. (2021). Influence of environmental factors on the ge-netic and chemical diversity of Brickellia veronicifolia populations growing in fragmented shrublands from Mexico. Plants, 10(2), 325. CrossRef
Pande H., Kumar B., & Varshney V.K. (2018). HPLC-ESI-QTOF-MS analysis of phenolic com-pounds, antioxidant capacity and α-glucosidase inhibitory effect of Bambusa nutans leaves. Indian Journal of Chemistry, 57B(7): 988–996. Direct Link.
Rassem H.H., Nour A.H., & Yunus R.M. (2018). Biological activities of essential oils-A review. Pa-cific International Journal, 01 (2): 1-14.
Roslan, A. S., Ismail, A., Ando, Y., & Azlan, A. (2020). Effect of drying methods and parameters on the antioxidant properties of tea (Camellia sinensis). Food Production, Processing and Nutri-tion, 2, 8. CrossRef
Şahin, S., Elhussein, E., Bilgin, M., Lorenzo, J. M., Barba, F. J., & Roohinejad, S. (2017). Effect of drying method on oleuropein, total phenolic content, flavonoid content, and antioxidant ac-tivity of olive (Olea europaea) leaf. Journal of Food Processing and Preservation, 42(5), e13604. CrossRef
Saifullah, M., McCullum, R., McCluskey, A., & Vuong, Q. (2019). Effects of different drying meth-ods on extractable phenolic compounds and antioxidant properties from lemon myrtle dried leaves. Heliyon, 5(12), e03044. CrossRef
Santos, A. E., Aguiar, G. P. S., Dal Magro, C., Lacowicz, R. A., Fedrigo, I. M. T., Bordignon-Luiz, M. T. Oliveira, J. V., & Lanza, M. (2022). Impact of drying method as pretreatment for extrac-tion of bioactive compounds from jambolan (Syzygium cumini (L.) Skeels). Brazilian Jour-nal of Food Technology, 25, e2021055. CrossRef
Scarano, P., Guida, R., Zuzolo, D., Tartaglia, M., Prigioniero, A., Postiglione, A., Pinto, G., Illiano, A., Amoresano, A., Schicchi, R., Geraci, A., Sciarrillo, R., & Guarino, C. (2022). An endemic plant of the mediterranean area: phytochemical characterization of strawberry tree (Arbu-tus unedo L.) fruits extracts at different ripening Stages. Frontiers in Nutrition, 9, 915994. CrossRef
Senouci, F., Ababou, A., & Chouieb, M. (2019). Ethnobotanical survey of the medicinal plants used in the southern mediterranean. Case study: the region of bissa (Northeastern Dahra Mountains, Algeria). Pharmacognosy Journal, 11(4), 647-59. CrossRef
Sharma, K., Ko, E. Y., Assefa, A. D., Ha, S., Nile, S. H., Lee, E. T. & Park, S. W. (2015). Temperature-dependent studies on the total phenolics, flavonoids, antioxidant activities, and sugar con-tent in six onion varieties. Journal of Food and Drug Analysis, 23(2), 243–252. CrossRef
Shi, L., Zhao, W., Yang, Z., Subbiah, V., Suleria, H.A.R. (2022). Extraction and characterization of phenolic compounds and their potential antioxidant activities. Environmental Science and Pollution Research, 29(54), 81112-81129. CrossRef
Singhal, S., Rasane, P., Kaur, S., Singh, J., & Gupta, N. (2020). Thermal degradation kinetics of bio-active compounds in button mushroom (Agaricus bisporus) during tray drying process. Journal of Food Process Engineering, 43(12), e13555. CrossRef
Sousa, M. N., Macedo, A. T., Ferreira, G. F., Furtado, H. L. A., Pinheiro, A. J. M. C. R., Lima-Neto, L. G., Fontes, V. C., Ferreira, R. L. P. S., Monteiro, C. A., Falcai, A., Gomes, L. N., Bragança, Q. D. S. R., Torres, D. D. S. B., Galvão, L. C. D. C., Holanda, R. A., & Santos, J. R. A. (2022). Hydroal-coholic leaf extract of Punica granatum, alone and in combination with calcium hydroxide, is effective against mono- and polymicrobial biofilms of Enterococcus Faecalis and Candida Albicans. Antibiotics, 11(5), 584. CrossRef
Sun, W., & Shahrajabian, M. H. (2023). Therapeutic potential of phenolic compounds in medicinal plants-natural health products for human health. Molecules, 28(4):1845. CrossRef
Stephenus, F. N., Benjamin, M. A. Z., Anuar, A. & Awang, M. A. (2023). Effect of temperatures on drying kinetics, extraction yield, phenolics, flavonoids, and antioxidant activity of Phaleria macrocarpa (Mahkota Dewa) fruits. Foods, 12(15), 2859. CrossRef
Tenuta, M. C., Tundis, R., Xiao, J., Loizzo, M. R., Dugay, A., & Deguin, B. (2019). Arbutus species (Ericaceae) as source of valuable bioactive products. Critical Reviews in Food Science and Nutrition, 59(6), 864-881. CrossRef
Tenuta, M. C., Deguin, B., Loizzo M. R., Dugay, A., Acquaviva, R., Malfa, G. A., Bonesi, M., Bouzidi, C., & Tundis, R. (2020). Contribution of flavonoids and iridoids to the hypoglycaemic, anti-oxidant, and nitric oxide (no) inhibitory activities of Arbutus unedo L. Antioxidants (Basel), 9(2), 184. CrossRef
Tirado-Kulieva, V. A., Hernandez-Martinez, E., & Choque-Rivera, T.J. (2022). Phenolic com-pounds versus SARS-CoV-2: An update on the main findings against COVID-19. Heliyon, 8, e10702. CrossRef
Vanielie, T. J., Muskhazli, M., Sulaiman, S. K. & Rusea, G. (2019). Effect of drying methods and ex-traction solvents on phenolic antioxidants and antioxidant activity of Scurrula ferruginea (Jack) Danser (Loranthaceae) leaf extract. Sains Malaysiana, 48(7), 1383–1393. CrossRef
Wanga, L., & Nyamboki, D. K. (2023). Medicinal plants used in the management of skin disorders in Kenya: A Review. Pharmacognosy Reviews, 17(33), 69-103. CrossRef
Yazan, R., Mohd Fadzelly, A., Nur Amalina, I., Faridah, K., Maryati, M., Abdah, M. A. & Azizul, I. (2021). Anti-aging and antioxidant of four traditional malaysian plants using simplex cen-troid mixture design approach. Saudi Journal of Biological Sciences, 28(12), 6711-6720. CrossRef
Youssef, F. S., Ramadan, M. F., Echeverria Moran, V., Aremu, A. O., & Mamadalieva, N. Z. (2022). Editorial: Potential of natural products as drug leads possessing antioxidant and anti-aging properties. Frontiers in Pharmacology,13, 1094950. CrossRef
Zemour, K., Labdelli, A., Adda, A., Dellal, A., Talou, T., & Merah, O. (2019). Phenol content and antioxidant and antiaging activity of safflower seed oil (Carthamus tinctorius L.). Cosmetics, 6(3), 55. CrossRef
Zemour, K., Adda, A., Labdelli, A., Dellal, A., Cerny, M., & Merah, O. (2021). Effects of genotype and climatic conditions on the oil content and its fatty acids composition of Carthamus tinc-torius L. seeds. Agronomy, 11(10), 2048. CrossRef
Zemour, K. (2022). Study of tolerance to water deficit and heat stress in safflower (Carthamus tinctorius L.) and their effects on oil yield and quality. (published doctoral thesis), University of Tiaret, Algeria and INP of Toulouse, France. (in French language)
Zhang, Z., Lv, G., Pan, H., Wu, Y., & Fan, L. (2009). Effects of different drying methods and extrac-tion condition on antioxidant properties of Shiitake (Lentinus edodes). Food Science and Technology Research, 15(5), 547-552. CrossRef
Złotek, U., Lewicki, S., Markiewicz, A., Szymanowska, U., & Jakubczyk, A. (2021). Effects of dry-ing methods on antioxidant, anti-inflammatory, and anticancer potentials of phenolic acids in lovage elicited by jasmonic acid and yeast extract. Antioxidants, 10(5), 662. CrossRef
Abidi, E., Habib, J., Yassine, A., Chahine, N., Mahjoub, T., & Elkak A. (2016). Effects of methanol extracts from roots, leaves, and fruits of the Lebanese strawberry tree (Arbutus andrachne) on cardiac function together with their antioxidant activity. Pharmaceutical Biology, 54(6), 1035-1041. CrossRef
Ahdaa, M., Jaswirb, I., Khatibd, A., Ahmed, Q. E., Mahfudha, N., & Ardini, Y.D. (2023). A review on selected herbal plants as alternative anti-diabetes drugs: chemical compositions, mecha-nisms of action, and clinical study. International journal of food properties, 26(1), 1414–1425. CrossRef
Ait lhaj, Z., Taghzouti, K., Bouyahya, A., Diria, G., Bakhy, K., & Bchitou R. (2022).Phenolic com-position and antioxidant activity of leaves of strawberry tree (Arbutus unedo L.) popula-tions from Morocco. Phytothérapie, 20(4-5), 192–204. CrossRef
Alghoraibi, I., Soukkarieh, C., Zein, R., Alahmad, A., Walter, J.G., & Daghestani, M. (2020). Aqueous extract of Eucalyptus camaldulensis leaves as reducing and capping agent in biosynthesis of silver nanoparticles. Inorganic and Nano-Metal Chemistry, 50(10), 1–8. CrossRef
Anwar F., Kalsoom U., Sultana B., Mushtaq M., Mehmood T., & Arshad H. A. (2013). Effect of dry-ing method and extraction solvent on the total phenolics and antioxidant activity of cauli-flower (Brassica oleracea L.) extracts. International Food Research Journal, 20(2), 653-659. Direct Link.
Ateş, U., Karakaya, O., Çelik, S.M., & Faizy, A.H. (2022). Bioactive compounds of strawberry tree (Arbutus unedo L.) genotypes grown in the East Black Sea and Marmara region. Turkish Journal of Food and Agriculture Sciences, 4 (2), 29-33. CrossRef
Baibuch, S., Zema, P., Bonifazi, E., Cabrera, G., Mondragón Portocarrero, A. D. C., Campos, C., & Malec, L. (2023). Effect of the drying method and optimization of extraction on antioxidant activity and phenolic of rose petals. Antioxidants, 12(3), 681. CrossRef
Bafandeh, S., Khodadadi, E., Ganbarov, K., Asgharzadeh, M., Köse, S., & Samadi Kafil, H. (2023). Natural products as a potential source of promising therapeutics for COVID-19 and viral diseases. Evidence-Based Complementary and Alternative Medicine, 2023, 5525165 Cross-Ref
Bakchiche, B., Gherib, A., Smail, A., Custódia, G., & Graça, M. M. (2013). Antioxidant activities of eight Algerian plant extracts and two essential oils. Industrial Crops and Products, 46: 85–96. CrossRef
Bebek Markovinovi´c, A., Brˇci´c Karaˇconji, I., Jurica, K., Lasi´c, D., Skendrovi´c Babojeli´c, M., Duralija, B., Šic Žlabur, J., Putnik, P., & Bursa´c Kovaˇcevi´c, D. (2022). Strawberry tree fruits and leaves (Arbutus unedo L.) as raw material for sustainable functional food processing: a review. Horticulturae, 8(10), 881. CrossRef
Benjamin, M. A. Z., Ng, S. Y., Saikim, F. H., & Rusdi, N. A. (2022). The effects of drying techniques on phytochemical contents and biological activities on selected bamboo leaves. Molecules, 27(19), 6458. CrossRef
Bertsouklis, K. F., Daskalakis, I., Biniari, K., & Papafotiou, M. (2021). Comparative study of poly-phenolic content and antioxidant capacity in fruits of Arbutus unedo, A. andrachne and their natural hybrid A.× andrachnoides. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 49(1), 12165. CrossRef
Bié, J., Sepodes, B., Fernandes, P.C.B. & Ribeiro, M.H.L. (2023). Polyphenols in health and disease: gut microbiota, bioaccessibility, and bioavailability. Compounds 3(1), 40-72. CrossRef
Chaikhong, K., Chumpolphant, S., Rangsinth, P., Sillapachaiyaporn, C., Chuchawankul, S., Ten-comnao, T., & Prasansuklab, A. (2023). Antioxidant and anti-skin aging potential of selected Thai plants: In vitro evaluation and in silico target prediction. Plants, 12(1), 65. CrossRef
Chaudhary, P., Janmeda, P., Docea, A. O., Yeskaliyeva, B., Abdull Razis, A. F., Modu, B., Calina, D., & Sharifi-Rad, J. (2023). Oxidative stress, free radicals and antioxidants: potential crosstalk in the pathophysiology of human diseases. Frontiers in Chemistry, 11, 1158198. CrossRef
Cör Andrejc, D., Butinar, B., Knez, Ž., Tomažiˇc, K., & Knez Marevci, M. (2022). The effect of dry-ing methods and extraction techniques on oleuropein content in olive leaves. Plants (Basel), 11(7), 865. CrossRef
Doudach, L., Naceiri Mrabti, H., Al-Mijalli, S. H., Kachmar, M. R., Benrahou, K., Assaggaf, H., Qasem, A., Abdallah, E. M., Rajab, B. S., Harraqui, K., Mekkaoui, M., Bouyahya, A., & El Ab-bes Faouzi, M. (2023). Phytochemical, antidiabetic, antioxidant, antibacterial, acute and sub-chronic toxicity of moroccan Arbutus unedo leaves. Journal Pharmacopuncture, 26(1), 27-37. CrossRef
Dutta, A. K., Gazi, M. S., & Uddin, S. J. (2023). A systemic review on medicinal plants and their bi-oactive constituents against avian influenza and further confirmation through in-silico analysis. Heliyon, 9, e14386. CrossRef
El Cadi, H., El Cadi, A., Kounnoun, A., Oulad El Majdoub, Y., Palma, L. M., Brigui, J., Dugo, P., Mondello, L., & Cacciola, F. (2020). Wild strawberry (Arbutus unedo): Phytochemical screening and antioxidant properties of fruits collected in northern Morocco. Arabian Jour-nal of Chemistry, 13(8), 6299-6311. CrossRef
El-Desouky, T. A. (2021). Evaluation of effectiveness aqueous extract for some leaves of wild edible plants in Egypt as anti-fungal and anti-toxigenic. Heliyon, 7(2), e06209. CrossRef
El Gamal, R., Song, C., Rayan, A. M., Liu, C., Al-Rejaie, S., & ElMasry, G. (2023). Thermal degrada-tion of bioactive compounds during drying process of horticultural and agronomic prod-ucts: A comprehensive overview. Agronomy, 13(6), 1580. CrossRef
El Mekkaoui, A., Khamar, M., Slimani, C., Nounah, A., Cherkaoui, E., Benradi, F., & Chaimae Raisi, C. (2023). Phytochemical studies and in vitro evaluation of the antioxidant activity of some medicinal and aromatic plants from Morocco. Notulea Scitia Biologicae, 15(1), 11423. CrossRef
El Zerey-Belaskri, A., Belyagoubi-Benhammou, N., & Benhassaini, H. (2022). From traditional knowledge to modern formulation: potential and prospects of Pistacia atlantica desf. es-sential and fixed oils uses in cosmetics. Cosmetics, 9(6), 109. CrossRef
Erdogan, G., & Uysal, T. (2020). Characterization of antioxidant properties of strawberry tree (Arbutus unedo L.) and trace elements determination. Journal of Research in Pharmacy, 24(5), 774–785. CrossRef
Erkekoglou, I., Nenadis, N., Samara, E., & Mantzouridou, F. T. (2017). Functional teas from the leaves of Arbutus unedo: phenolic content, antioxidant activity, and detection of efficient radical scavengers. Plant Foods for Human Nutrition, 72(2), 176-183. CrossRef
Frimpong, E. K., Asong, J. A., & Aremu, A. O. (2021). A review on medicinal plants used in the management of headache in Africa. Plants, 10(10), 2038. CrossRef
García-Ramón, F., Malnati-Ramos, M., Rios-Mendoza, J., Vivar-Méndez, J., Nieva-Villegas, L.M., Cornelio-Santiago, H.P., Sotelo-Méndez, A. (2023). Avocado Hass peel from industrial by-product: effect of extraction process variables on yield, phenolic compounds and antioxi-dant capacity. Frontiers in Sustainable Food Systems, 7:1255941. CrossRef
Guclu, G., Keser, D., Kelebek, H., Keskin, M., Emre Sekerli, Y., Soysal, Y., & Selli, S. (2021). Impact of production and drying methods on the volatile and phenolic characteristics of fresh and powdered sweet red peppers. Food Chemistry, 338, 128129. CrossRef
Habachi, E., Rebey, I. B., Dakhlaoui, S., Hammami, M., Sawsen, S., Msaada, K., Merah, O., & Bour-gou, S. (2022). Arbutus unedo: Innovative source of antioxidant, anti-inflammatory and anti-tyrosinase phenolics for novel cosmeceuticals. Cosmetics, 9(6), 143. CrossRef
Haris, A., Nawan, N. A., Mei, C. A. L., Sani, S. A., & Najm, S. U. F. S. (2023). Medicinal plant applica-tions as traditional and complementary medicine by sabah ethnicities and the regulations and economic view in Malaysia's healthcare industry: A mini review. Pharmacognosy Re-views, 17(33), 1-10. CrossRef
Hmaidosh D., Ali M., & Salame R. (2020). Evaluation of antioxidant activity and the phenolic composition of Syrian Arbutus andrachne L. Future of Food: Journal on Food, Agriculture and Society, 8 (3): 1-7. Direct Link.
Jurič A., Gašić U., Karačonji I.B., Jurica K., & Milojković-Opsenica D. (2020). The phenolic profile of strawberry tree (Arbutus unedo L.) honey. Journal of the Serbian Chemical Society, 85 (8): 1011–1019. Direct Link.
Kachkoul, R., Squalli Housseini, T., Mohim, M., El Habbani, R., Miyah, Y., & Lahrichi, A. (2019). Chemical compounds as well as antioxidant and litholytic activities of Arbutus unedo L. leaves against calcium oxalate stones. Journal of integrative medicine, 17(6):430–437. CrossRef
Kim, Y.J. & Kang, K.S. (2023). The phytochemical constituents of medicinal plants for the treatment of chronic inflammation. Biomolecules, 13, 1162. CrossRef
Kumar, A.P.N., Kumar, M., Jose, A., Tomer, V., Oz, E., Proestos, C., Zeng, M., Elobeid, T.K.S., & Oz, F. (2023). Major phytochemicals: recent advances in health benefits and extraction method. Molecules. 28(2):887. CrossRef
Labdelli, A., Zemour, K., Simon, V., Cerny, M., Adda, A., & Merah, O. (2019). Pistacia atlantica Desf., a source of healthy vegetable oil. Applied Sciences, 9(12), 2552. CrossRef
Lang, H. G., Lindemann, J. S., Ferreira, D. C., Hoffmann, J. F., Vanier, N. L., & de Oliveira, M. (2019). Effects of drying temperature and long-term storage conditions on black rice phe-nolic compounds. Food Chemistry, 287, 197–204. CrossRef
Laouicha S., Senator A., Kherbache A., & Bouriche H. (2020). Total phenolic contents and an-tioxidant properties of Algerian Arbutus unedo L. extracts. Journal of Drug Delivery and Therapeutics, 10(3-s): 159-168. CrossRef
Lee, S. Y., Ferdinand, V., & Siow, L. F. (2022). Effect of drying methods on yield, physicochemical properties, and total polyphenol content of chamomile extract powder. Frontiers Pharma-cology, 13, 1003209. CrossRef
Lehfa, F., Belkhodja, H., & Sahnouni, F. (2023) Phytochemical screening, antioxidant and anti-inflammatory activities of polyphenolic extracts of strawberry-tree fruits (Arbutus unedo L). Journal of Applied Biotechnology Reports, 10(2), 992-999. CrossRef
Lenzi, M., Turrini, E., Catanzaro, E., Cocchi, V., Guerrini, A., Hrelia, P., Gasperini, S., Stefanelli, C., Abdi Bellau, M. L., Pellicioni, V., Tacchini, M., Greco, G., & Fimognari, C. (2022). In vitro in-vestigation of the anticancer properties of Ammodaucus Leucotrichus Coss. & Dur. Pharma-ceuticals, 15(12), 1491. CrossRef
Martemucci, G., Costagliola, C., Mariano, M., D’andrea, L., Napolitano, P., & D’Alessandro, A. G. (2022). Free radical properties, source and targets, antioxidant consumption and health. Oxygen, 2(2), 48–78. CrossRef
Miguel, M. G., Faleiro, M. L., Guerreiro, A. C., & Antunes, M. D. (2014). Arbutus unedo L.: chemical and biological properties. Molecules, 19(10), 15799–15823. CrossRef
Morales, D. (2022). Use of strawberry tree (Arbutus unedo) as a source of functional fractions with biological activities. Foods, 11(23), 3838. CrossRef
Morgado, S., Morgado, M., Plácido A. I., Roque, F., & Duarte, A. P. (2018). Arbutus unedo L.: From traditional medicine to potential uses in modern pharmacotherapy. Journal of Ethnophar-macology, 225, 90-102. CrossRef
Moualek, I., Iratni, A.G., Mestar, G.N., Souad, L., & Houali, K. (2016). Antioxidant and anti-inflammatory activities of Arbutus unedo aqueous extract. Asian Pacific Journal of Tropical Biomedicine, 6(11), 933-944. CrossRef
Mrabti H.N., Marmouzi I., Sayah K., Chemlal L., El Ouadi Y., Elmsellem H., Cherrah Y., & Faouzi M.A. (2017). Arbutus unedo L. aqueous extract is associated with in vitro and in vivo antiox-idant activity. Journal of materials and Environmental Sciences, 8(1): 217–224. Direct Link.
Muflihah, Y. M., Gollavelli, G., & Ling, Y. C. (2021). Correlation study of antioxidant activity with phenolic and flavonoid compounds in 12 Indonesian indigenous herbs. Antioxidants, 10(10), 1530. CrossRef
Nafeh, G., Abi Akl, M., Samarani, J., Bahous, R., Al Kari, G., Younes, M., Sarkis, R., Rizk, S. (2023). Urtica dioica leaf infusion enhances the sensitivity of triple-negative breast cancer cells to cisplatin treatment. Pharmaceuticals, 16, 780. CrossRef
Nisar, B., Sultan, A., & Rubab, S. (2018). Comparison of medicinally important natural products versus synthetic drugs-A short commentary. Natural Products Chemistry & Research, 6, 2. CrossRef
Nurhaslina, C. R., Andi Bacho, S., & Mustapa, A. N. (2022). Review on drying methods for herbal plants. Materials Today: Proceedings, 63(1), S122-S139. CrossRef
Pacheco-Hernández, Y., Villa-Ruano, N., Lozoya-Gloria, E., Barrales-Cortés, C. A., Jiménez-Montejo, F. E., & Cruz-López, M. D. C. (2021). Influence of environmental factors on the ge-netic and chemical diversity of Brickellia veronicifolia populations growing in fragmented shrublands from Mexico. Plants, 10(2), 325. CrossRef
Pande H., Kumar B., & Varshney V.K. (2018). HPLC-ESI-QTOF-MS analysis of phenolic com-pounds, antioxidant capacity and α-glucosidase inhibitory effect of Bambusa nutans leaves. Indian Journal of Chemistry, 57B(7): 988–996. Direct Link.
Rassem H.H., Nour A.H., & Yunus R.M. (2018). Biological activities of essential oils-A review. Pa-cific International Journal, 01 (2): 1-14.
Roslan, A. S., Ismail, A., Ando, Y., & Azlan, A. (2020). Effect of drying methods and parameters on the antioxidant properties of tea (Camellia sinensis). Food Production, Processing and Nutri-tion, 2, 8. CrossRef
Şahin, S., Elhussein, E., Bilgin, M., Lorenzo, J. M., Barba, F. J., & Roohinejad, S. (2017). Effect of drying method on oleuropein, total phenolic content, flavonoid content, and antioxidant ac-tivity of olive (Olea europaea) leaf. Journal of Food Processing and Preservation, 42(5), e13604. CrossRef
Saifullah, M., McCullum, R., McCluskey, A., & Vuong, Q. (2019). Effects of different drying meth-ods on extractable phenolic compounds and antioxidant properties from lemon myrtle dried leaves. Heliyon, 5(12), e03044. CrossRef
Santos, A. E., Aguiar, G. P. S., Dal Magro, C., Lacowicz, R. A., Fedrigo, I. M. T., Bordignon-Luiz, M. T. Oliveira, J. V., & Lanza, M. (2022). Impact of drying method as pretreatment for extrac-tion of bioactive compounds from jambolan (Syzygium cumini (L.) Skeels). Brazilian Jour-nal of Food Technology, 25, e2021055. CrossRef
Scarano, P., Guida, R., Zuzolo, D., Tartaglia, M., Prigioniero, A., Postiglione, A., Pinto, G., Illiano, A., Amoresano, A., Schicchi, R., Geraci, A., Sciarrillo, R., & Guarino, C. (2022). An endemic plant of the mediterranean area: phytochemical characterization of strawberry tree (Arbu-tus unedo L.) fruits extracts at different ripening Stages. Frontiers in Nutrition, 9, 915994. CrossRef
Senouci, F., Ababou, A., & Chouieb, M. (2019). Ethnobotanical survey of the medicinal plants used in the southern mediterranean. Case study: the region of bissa (Northeastern Dahra Mountains, Algeria). Pharmacognosy Journal, 11(4), 647-59. CrossRef
Sharma, K., Ko, E. Y., Assefa, A. D., Ha, S., Nile, S. H., Lee, E. T. & Park, S. W. (2015). Temperature-dependent studies on the total phenolics, flavonoids, antioxidant activities, and sugar con-tent in six onion varieties. Journal of Food and Drug Analysis, 23(2), 243–252. CrossRef
Shi, L., Zhao, W., Yang, Z., Subbiah, V., Suleria, H.A.R. (2022). Extraction and characterization of phenolic compounds and their potential antioxidant activities. Environmental Science and Pollution Research, 29(54), 81112-81129. CrossRef
Singhal, S., Rasane, P., Kaur, S., Singh, J., & Gupta, N. (2020). Thermal degradation kinetics of bio-active compounds in button mushroom (Agaricus bisporus) during tray drying process. Journal of Food Process Engineering, 43(12), e13555. CrossRef
Sousa, M. N., Macedo, A. T., Ferreira, G. F., Furtado, H. L. A., Pinheiro, A. J. M. C. R., Lima-Neto, L. G., Fontes, V. C., Ferreira, R. L. P. S., Monteiro, C. A., Falcai, A., Gomes, L. N., Bragança, Q. D. S. R., Torres, D. D. S. B., Galvão, L. C. D. C., Holanda, R. A., & Santos, J. R. A. (2022). Hydroal-coholic leaf extract of Punica granatum, alone and in combination with calcium hydroxide, is effective against mono- and polymicrobial biofilms of Enterococcus Faecalis and Candida Albicans. Antibiotics, 11(5), 584. CrossRef
Sun, W., & Shahrajabian, M. H. (2023). Therapeutic potential of phenolic compounds in medicinal plants-natural health products for human health. Molecules, 28(4):1845. CrossRef
Stephenus, F. N., Benjamin, M. A. Z., Anuar, A. & Awang, M. A. (2023). Effect of temperatures on drying kinetics, extraction yield, phenolics, flavonoids, and antioxidant activity of Phaleria macrocarpa (Mahkota Dewa) fruits. Foods, 12(15), 2859. CrossRef
Tenuta, M. C., Tundis, R., Xiao, J., Loizzo, M. R., Dugay, A., & Deguin, B. (2019). Arbutus species (Ericaceae) as source of valuable bioactive products. Critical Reviews in Food Science and Nutrition, 59(6), 864-881. CrossRef
Tenuta, M. C., Deguin, B., Loizzo M. R., Dugay, A., Acquaviva, R., Malfa, G. A., Bonesi, M., Bouzidi, C., & Tundis, R. (2020). Contribution of flavonoids and iridoids to the hypoglycaemic, anti-oxidant, and nitric oxide (no) inhibitory activities of Arbutus unedo L. Antioxidants (Basel), 9(2), 184. CrossRef
Tirado-Kulieva, V. A., Hernandez-Martinez, E., & Choque-Rivera, T.J. (2022). Phenolic com-pounds versus SARS-CoV-2: An update on the main findings against COVID-19. Heliyon, 8, e10702. CrossRef
Vanielie, T. J., Muskhazli, M., Sulaiman, S. K. & Rusea, G. (2019). Effect of drying methods and ex-traction solvents on phenolic antioxidants and antioxidant activity of Scurrula ferruginea (Jack) Danser (Loranthaceae) leaf extract. Sains Malaysiana, 48(7), 1383–1393. CrossRef
Wanga, L., & Nyamboki, D. K. (2023). Medicinal plants used in the management of skin disorders in Kenya: A Review. Pharmacognosy Reviews, 17(33), 69-103. CrossRef
Yazan, R., Mohd Fadzelly, A., Nur Amalina, I., Faridah, K., Maryati, M., Abdah, M. A. & Azizul, I. (2021). Anti-aging and antioxidant of four traditional malaysian plants using simplex cen-troid mixture design approach. Saudi Journal of Biological Sciences, 28(12), 6711-6720. CrossRef
Youssef, F. S., Ramadan, M. F., Echeverria Moran, V., Aremu, A. O., & Mamadalieva, N. Z. (2022). Editorial: Potential of natural products as drug leads possessing antioxidant and anti-aging properties. Frontiers in Pharmacology,13, 1094950. CrossRef
Zemour, K., Labdelli, A., Adda, A., Dellal, A., Talou, T., & Merah, O. (2019). Phenol content and antioxidant and antiaging activity of safflower seed oil (Carthamus tinctorius L.). Cosmetics, 6(3), 55. CrossRef
Zemour, K., Adda, A., Labdelli, A., Dellal, A., Cerny, M., & Merah, O. (2021). Effects of genotype and climatic conditions on the oil content and its fatty acids composition of Carthamus tinc-torius L. seeds. Agronomy, 11(10), 2048. CrossRef
Zemour, K. (2022). Study of tolerance to water deficit and heat stress in safflower (Carthamus tinctorius L.) and their effects on oil yield and quality. (published doctoral thesis), University of Tiaret, Algeria and INP of Toulouse, France. (in French language)
Zhang, Z., Lv, G., Pan, H., Wu, Y., & Fan, L. (2009). Effects of different drying methods and extrac-tion condition on antioxidant properties of Shiitake (Lentinus edodes). Food Science and Technology Research, 15(5), 547-552. CrossRef
Złotek, U., Lewicki, S., Markiewicz, A., Szymanowska, U., & Jakubczyk, A. (2021). Effects of dry-ing methods on antioxidant, anti-inflammatory, and anticancer potentials of phenolic acids in lovage elicited by jasmonic acid and yeast extract. Antioxidants, 10(5), 662. CrossRef